ongoing CLINICAL TRIALS
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Research Navigators in the Clinical Trials Office are available to assist you by phone Monday through Friday, from 8:00 AM to 4:30 PM (excluding holidays), at 814-940-1212.
Alpha-1 Antitrypsin Deficiency
NCT05856331 (Past Study)
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema (ELEVAATE).
Allergic Bronchopulmonary Aspergillosis
NCT04442269 (Past Study)
Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED).
Asthma
NCT06977581 (Active)
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma.
NCT06979323 (Active)
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study (IMAGINE).
NCT07456033 (Active)
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma (MODIFY).
214579 (Active, Not Recruiting)
Global Multicenter Observational Study to Prospectively Describe the Real-World Effectiveness of Depemokimab in Patients With Asthma With Type 2 Inflammation (STRIDE-A).
BEL512-1101 (Active, Not Recruiting)
A Phase 1 Study to Evaluate the Safety and Tolerability of BEL512 in Healthy Participants and Participants With Mild-to-Moderate Asthma.
NCT06376045 (Active, Not Recruiting)
A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma.
NCT06422689 (Active, Not Recruiting)
Combination Short-Acting Bronchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care (ANCHOR).
NCT06496607 (Active, Not Recruiting)
A Study to Evaluate Solriktug in Adult Participants With Asthma (RAINIER).
NCT06609239 (Active, Not Recruiting)
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma (AIRPHRODITE).
NCT06676319 (Active, Not Recruiting)
Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma (AIRLYMPUS).
NCT06750289 (Active, Not Recruiting)
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment (BRISOTE).
NHF 009-011 (Active, Not Recruiting)
A Study Evaluating Nasal High-Flow Therapy in Participants With Asthma (NOBLE).
NCT04609878 (Past Study)
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS).
NCT04718389 (Past Study)
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype (NIMBLE).
NCT05329194 (Past Study)
Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States (PASSAGE).
NCT06261957 (Past Study)
A Study to Assess and Compare Safety and Tolerability of 3 Months Treatment With Salbutamol Administered Via MDI Containing Propellant HFA-152a or HFA-134a in Participants 12 Years of Age and Older With Asthma.
NCT03373045 (Past Study)
Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE).
NCT04718103 (Past Study)
A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype (SWIFT-2).
NCT05243680 (Past Study)
An Open-Label Extension Study of GSK3511294 (Depemokimab) in Participants Who Were Previously Enrolled in 206713 (NCT04719832) or 213744 (NCT04718103).
NCT05251259 (Past Study)
Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma (FLASH).
NCT05274815 (Past Study)
Study to Evaluate Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma (WAYFINDER).
NCT05552508 (Past Study)
BURAN: Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging.
NCT06102005 (Past Study)
Dose Ranging Study of Lunsekimig Compared With Placebo-control in Adult Participants With Moderate-to-severe Asthma (AIRCULES).
NCT06372496 (Past Study)
Pragmatic Open-Label Randomized Clinical Trial of FF/UMEC/VI vs Non-ellipta Usual Care ICS-LABA for Adult Participants With Uncontrolled Asthma (PERFORM).
NCT06502366 (Past Study)
A Study to Investigate the Effect on Lung Function of BDA Formulated With a Next Generation Propellant Compared With an Approved Asthma Treatment in Participants With Asthma.
NCT06572228 (Past Study)
Efficacy of Dupilumab Added to Medium Dose ICS/LABA Compared With Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma (AIM4).
NCT06748053 (Past Study)
A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma.
NCT06932263 (Past Study)
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids (UMBRIEL).
Bronchiectasis
NCFB01 (Active)
A Study of 24 to 52 Weeks of Treatment to Evaluate the Efficacy and Safety of Galvokimig in Adults With Non-Cystic Fibrosis Bronchiectasis (ATMOS).
NCT07201051 (Active)
A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis.
NCT06872892 (Active, Not Recruiting)
The AIRTIVITY Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis.
NCT07547436 (Active, Not Recruiting)
A Study to Assess Activity and Safety With SAR445399 Compared With Placebo in Adults With Non-Cystic Fibrosis Bronchiectasis.
NCT06280391 (Past Study)A Randomized, Double-blind, Placebo-controlled, Parallel-group, Proof-of-Concept (PoC) Study to Assess the Efficacy, Safety and Tolerability of Itepekimab, in Participants With Non-cystic Fibrosis Bronchiectasis (ACT18018).
19BR0001 (Past Study)
Target Validation and Discovery in Idiopathic Bronchiectasis (TARGET).
Chronic Cough
NCT07671911 (Active)
Idiopathic Pulmonary Fibrosis-Related Chronic Cough Reduction With Nalbuphine Extended-Release Tablets (OCEAN-1).
NCT05599191 (Active, Not Recruiting)
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-1).
NCT05660850 (Past Study)
A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough.
COPD
COPD01 (Active)
A Study of 24 to 52 Weeks of Treatment to Evaluate the Efficacy and Safety of Galvokimig in Participants With Moderate-to-Severe COPD With Chronic Bronchitis (SCALA).
J2S-MC-GZMV (Active)
A Study Evaluating an Investigational Treatment in Adults With Chronic Obstructive Pulmonary Disease (RENEW-COPD).
NCT05204888 (Active)
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home - a Multi-center Randomized Controlled Trial.
NCT06883305 (Active)
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adults With Moderate to Very Severe COPD (EMBARK).
NCT06891755 (Active)
Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung - Study 3 (BREATHE-3).
NCT06961214 (Active)
Depemokimab as an Extended Treatment Duration Biologic in Adults With COPD and Type 2 Inflammation (ENDURA-2).
NCT07051707 (Active)
Evaluating the Safety and Efficacy of the dNerva Lung Denervation System in Patients With COPD (AIRFLOW-4).
NCT07053423 (Active)
A Study to Investigate Airway Inflammation With Dupilumab in Participants With COPD (AEOLUS).
NCT07082738 (Active)
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe COPD (PRESTO).
NCT07177339 (Active)
Evaluating the Efficacy and Safety of Initiating Depemokimab Early Therapy in COPD With Type 2 Inflammation (VIGILANT).
NCT07363694 (Active)
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
NCT07610395 (Active)
Trial Comparing the Safety and Efficacy of Two Different Oral Vapendavir Doses With Placebo as Treatment for Rhinovirus in Participants With COPD (Cardinal COPD).
NCT07646587 (Active)
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius).
NCT07684820 (Active)
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment (Navigator).
223598 (Active, Not Recruiting)
Real-World Effectiveness of Mepolizumab in Treating Chronic Obstructive Pulmonary Disease: A Multi-Country Prospective Study (REALITI-C).
NCT04186546 (Active, Not Recruiting)
Zephyr Valve Registry (ZEVR).
NCT05742802 (Active, Not Recruiting)
Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).
NCT05878769 (Active, Not Recruiting)
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With COPD.
NCT06208306 (Active, Not Recruiting)
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD (AERIFY-4).
NCT06496620 (Active, Not Recruiting)
A Study to Evaluate Solrikitug in Participants With COPD (ZION).
NCT07016412 (Active, Not Recruiting)
A Phase IIb Ensifentrine-Glycopyrrolate Fixed-Dose Combination Dose-Ranging Study in Participants With COPD.
NCT03893370 (Past Study)
RejuvenAir® System Trial for COPD With Chronic Bronchitis (SPRAY).
NCT04053634 (Past Study)
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations (RESOLUTE).
NCT04320342 (Past Study)
A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD (TRITON).
NCT04701983 (Past Study)
Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD) (AERIFY-1).
NCT05166889 (Past Study)
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations (OBERON).
NCT05326412 (Past Study)
Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD (AERIFY 3).
NCT05595642 (Past Study)
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (ARNASA).
NCT06283966 (Past Study)
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease (THARROS).
EFC22927 (Past Study)
A Study Evaluating the Efficacy and Safety of Itepekimab in Participants With Chronic Obstructive Pulmonary Disease (AERIFY 5).
NCT04133909 (Past Study)
Mepolizumab as Add-on Treatment in Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level (MATINEE).
NCT04456673 (Past Study)
Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation (NOTUS).
NCT06533553 (Past Study)
A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD.
Pulmonary Fibrosis
NCT07284602 (Active)
Trial to Evaluate the Efficacy and Safety of LYT-100 Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (SURPASS-IPF).
ORJ-001-01 (Active)
A Study Evaluating an Investigational Treatment in Adults With Idiopathic Pulmonary Fibrosis (ORBIT-IPF).
NCT06097260 (Past Study)
Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis.
BI1490-0004 (Past Study)
A Study to Test Whether BI 1839100 Improves Cough in People With Idiopathic Pulmonary Fibrosis or Progressive Pulmonary Fibrosis.
NCT06335303 (Past Study)
A Study to Test Whether BI 1819479 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF).
Lung Cancer
NCT06122077 (Active)
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening.
NCT07168993 (Active)
Clinical Performance of the FlowPath Lung Test to Detect Lung Cancer in High-Risk Individuals With Lung Nodules.
P-040101 (Active)
A Study Evaluating the Clinical Performance of the THOR Blood-Based Test for Lung Cancer Detection.
DHF 007 078 (Active, Not Recruiting)
A Clinical Utility Study Evaluating How a Blood-Based Lung Nodule Test Affects Patient Management.
DHF 009-053P (Active, Not Recruiting)
Clinical Utility of Management of Patients With CT- and LDCT-Identified Pulmonary Nodules Using the Percepta Nasal Swab Classifier (NIGHTINGALE).
NCT05306288 (Active, Not Recruiting)
CASCADE-LUNG: Cancer Screening Assay Using DELFI; A Clinical Validation Study in Lung.
NCT05987189 (Active, Not Recruiting)
Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung (BOSTON II).
NCT06728319 (Active, Not Recruiting)
A Multicenter, Retrospective Chart Review Evaluating the Impact and Utility of Blood-Based Proteomic and Auto-Antibody Tests in the Real World.
P-030101 (Active, Not Recruiting)
A Study Evaluating the Clinical Performance of the APOLLO Blood-Based Test for Lung Cancer Detection.
2022-BR-0001 (Past Study)
A Study Evaluating Fluoroscopy Use During Robotic-Assisted Bronchoscopy for Pulmonary Lesion Procedures (J&J FLUOROSCOPY).
DHF007072 (Past Study)
A Study Evaluating a Single-Tube Blood Collection Method for Lung Cancer Testing (SINGLE TUBE).
GO44296 (Past Study)
A Cancer Screening Collection Study Evaluating Blood-Based Biomarkers for Early Detection of Lung and Colorectal Cancer (LIGHTHOUSE).
Obesity
NCT07667803 (Active)
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without Type 2 Diabetes Mellitus (EMBOLD).